• Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
1993 …2021

Research activity per year

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Personal profile

Research Overview

Prof. Orlando's lab is interested in investigating the chromatin mediated fundamental mechanisms that control cell identity and plasticity. These include signaling to chromatin regulation and nuclear organization by Polycomb proteins, the role of ncRNA-protein interactions in transcriptional regulation, Epigenomics and how this relates for development, transdifferentiation and adaptation (e.g. Metabolism), in particular in stress conditions. Furthermore, as part of the mechanistic plastic properties of the genome in response to developmental and environmental cues, Prof. Orlando's lab also investigates the epigenetic regulation of the expression and dynamics of transposable elements and their role in cell differentiation and epigenomic biodiversity.

Key Research Areas

Epigenetics

Expertise related to UN SDGs

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 15 - Life on Land

Education

Ph.D., University of Rome La Sapienza

1989

Award Date: Jan 1 1989

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  • Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome.

    Laricchiuta, D., Sciamanna, G., Gimenez, J., Termine, A., Fabrizio, C., Caioli, S., Balsamo, F., Panuccio, A., De Bardi, M., Saba, L., Passarello, N., Cutuli, D., Mattioni, A., Zona, C., Orlando, V. & Petrosini, L., Jan 20 2021, In: International journal of molecular sciences. 22, 2, p. 810

    Research output: Contribution to journalArticlepeer-review

  • Functional annotation of human long noncoding RNAs via molecular phenotyping.

    Ramilowski, J. A., Yip, C. W., Agrawal, S., Chang, J-C., Ciani, Y., Kulakovskiy, I. V., Mendez, M., Ooi, J. L. C., Ouyang, J. F., Parkinson, N., Petri, A., Roos, L., Severin, J., Yasuzawa, K., Abugessaisa, I., Akalin, A., Antonov, I. V., Arner, E., Bonetti, A., Bono, H. & 96 others, Borsari, B., Brombacher, F., Cameron, C. J. F., Cannistraci, C. V., Cardenas, R., Cardon, M., Chang, H., Dostie, J., Ducoli, L., Favorov, A., Fort, A., Garrido, D., Gil, N., Gimenez, J., Guler, R., Handoko, L., Harshbarger, J., Hasegawa, A., Hasegawa, Y., Hashimoto, K., Hayatsu, N., Heutink, P., Hirose, T., Imada, E. L., Itoh, M., Kaczkowski, B., Kanhere, A., Kawabata, E., Kawaji, H., Kawashima, T., Kelly, S. T., Kojima, M., Kondo, N., Koseki, H., Kouno, T., Kratz, A., Kurowska-Stolarska, M., Kwon, A. T. J., Leek, J., Lennartsson, A., Lizio, M., López-Redondo, F., Luginbühl, J., Maeda, S., Makeev, V. J., Marchionni, L., Medvedeva, Y. A., Minoda, A., Müller, F., Muñoz-Aguirre, M., Murata, M., Nishiyori, H., Nitta, K. R., Noguchi, S., Noro, Y., Nurtdinov, R., Okazaki, Y., Orlando, V., Paquette, D., Parr, C. J. C., Rackham, O. J. L., Rizzu, P., Sánchez Martinez, D. F., Sandelin, A., Sanjana, P., Semple, C. A. M., Shibayama, Y., Sivaraman, D. M., Suzuki, T., Szumowski, S. C., Tagami, M., Taylor, M. S., Terao, C., Thodberg, M., Thongjuea, S., Tripathi, V., Ulitsky, I., Verardo, R., Vorontsov, I. E., Yamamoto, C., Young, R. S., Baillie, J. K., Forrest, A. R. R., Guigó, R., Hoffman, M. M., Hon, C. C., Kasukawa, T., Kauppinen, S., Kere, J., Lenhard, B., Schneider, C., Suzuki, H., Yagi, K., de Hoon, M. J. L., Shin, J. W. & Carninci, P., Jul 29 2020, In: Genome research.

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations
  • RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions

    Bonetti, A., Agostini, F., Suzuki, A. M., Hashimoto, K., Pascarella, G., Gimenez, J., Roos, L., Nash, A. J., Ghilotti, M., Cameron, C. J. F., Valentine, M., Medvedeva, Y. A., Noguchi, S., Agirre, E., Kashi, K., Samudyata, Luginbühl, J., Cazzoli, R., Agrawal, S., Luscombe, N. M. & 9 others, Blanchette, M., Kasukawa, T., Hoon, M. D., Arner, E., Lenhard, B., Plessy, C., Castelo-Branco, G., Orlando, V. & Carninci, P., Feb 24 2020, In: Nature Communications. 11, 1

    Research output: Contribution to journalArticlepeer-review

    20 Scopus citations
  • Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements.

    Della Valle, F., Thimma, M. P., Caiazzo, M., Pulcrano, S., Celii, M., Adroub, S. A., Liu, P., Alanis Lobato, G., Broccoli, V. & Orlando, V., Jan 2 2020, In: Stem Cell Reports. 14, 1, p. 60-74 15 p.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations
  • Nuclear AGO1 Regulates Gene Expression by Affecting Chromatin Architecture in Human Cells.

    Shuaib, M., Parsi, K. M., Thimma, M., Adroub, S., Kawaji, H., Seridi, L., Ghosheh, Y., Fort, A., Fallatah, B., Ravasi, T., Carninci, P. & Orlando, V., Oct 21 2019, In: Cell systems. 9, 5, p. 446-458.e6 457999555 p.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

    Dyar, K. A., Lutter, D., Artati, A., Ceglia, N. J., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., Abbondante, S., Tognini, P., Orozco-Solis, R., Kinouchi, K., Wang, C., Swerdloff, R., Nadeef, S., Masri, S., Magistretti, P., Orlando, V. & 7 others, Borrelli, E., Uhlenhaut, N. H., Baldi, P., Adamski, J., Tschöp, M. H., Eckel-Mahan, K. & Sassone-Corsi, P., Sep 6 2018, In: Cell. 174, 6, p. 1571-1585.e11

    Research output: Contribution to journalArticlepeer-review

    83 Scopus citations
  • How Polycomb-Mediated Cell Memory Deals With a Changing Environment

    Marasca, F., Bodega, B. & Orlando, V., Mar 9 2018, In: BioEssays. 40, 4, p. 1700137

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations
  • A cytosolic Ezh1 isoform modulates a PRC2–Ezh1 epigenetic adaptive response in postmitotic cells

    Bodega, B., Marasca, F., Ranzani, V., Cherubini, A., Valle, F. D., Neguembor, M. V., Wassef, M., Zippo, A., Lanzuolo, C., Pagani, M. & Orlando, V., Mar 27 2017, In: Nature Structural & Molecular Biology. 24, 5, p. 444-452 9 p.

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations
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