Research output per year
Research output per year
Personal profile
Research Overview
Professor Hamdan's research interest is focused on the reconstitution, imaging and characterization of multi-protein nucleic acid binding machinaries at the single molecule level. Toward achieving this goal his lab uses an approach that combines conventional biochemical and biophysical tools with wide range of force and fluorescence single-molecule imaging techniques.
The ability to observe enzymatic activities in real time at the single molecule level has profoundly changed how biochemical reactions are studied.
By eliminating ensemble averaging, the distributions and fluctuations of molecular properties can be characterized, transient intermediates can be observed and identified, and catalytic mechanisms can be elucidated. Applying this multidisciplinary approach will provide a true molecular understanding of the mechanisms involved in replication, repair, and recombination.
It will also extend the technique of single-molecule analysis from a few proteins to large multi-protein complexes, often containing many enzymatic activities.
Key Research Areas
Chemical Science
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education
Chemistry, Ph.D., Australian National University
2002
Award Date: Jan 1 2002
Chemistry, M.S., Western Michigan University
1998
Award Date: Jan 1 1998
Chemistry, B.S., Yarmouk University
1995
Award Date: Jan 1 1995
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DNA primase acts as a molecular brake in DNA replication
Lee, J. B., Hite, R. K., Hamdan, S. M., Xie, X. S., Richardson, C. C. & Van Oijen, A. M., Feb 2 2006, In: Nature. 439, 7076, p. 621-624 4 p.Research output: Contribution to journal › Article › peer-review
221 Scopus citations -
Single-molecule studies of fork dynamics in Escherichia coli DNA replication
Tanner, N. A., Hamdan, S. M., Jergic, S., Schaeffer, P. M., Dixon, N. E. & Van Oijen, A. M., Feb 1 2008, In: Nature Structural and Molecular Biology. 15, 2, p. 170-176 7 p.Research output: Contribution to journal › Article › peer-review
104 Scopus citations -
Structural basis for proofreading during replication of the Escherichia coli chromosome
Hamdan, S., Carr, P. D., Brown, S. E., Ollis, D. L. & Dixon, N. E., Apr 23 2002, In: Structure. 10, 4, p. 535-546 12 p.Research output: Contribution to journal › Article › peer-review
118 Scopus citations -
Motors, switches, and contacts in the replisome
Hamdan, S. & Richardson, C. C., Jul 24 2009, In: Annual Review of Biochemistry. 78, p. 205-243 39 p.Research output: Contribution to journal › Article › peer-review
128 Scopus citations -
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis
Hamdan, S. M., Loparo, J. J., Takahashi, M., Richardson, C. C. & Van Oijen, A. M., Jan 15 2009, In: Nature. 457, 7227, p. 336-339 4 p.Research output: Contribution to journal › Article › peer-review
118 Scopus citations -
Dynamic DNA Helicase-DNA Polymerase Interactions Assure Processive Replication Fork Movement
Hamdan, S. M., Johnson, D. E., Tanner, N. A., Lee, J. B., Qimron, U., Tabor, S., van Oijen, A. M. & Richardson, C. C., Aug 17 2007, In: Molecular Cell. 27, 4, p. 539-549 11 p.Research output: Contribution to journal › Article › peer-review
86 Scopus citations -
A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor
Hamdan, S., Marintcheva, B., Cook, T., Lee, S. J., Tabor, S. & Richardson, C. C., Apr 5 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 14, p. 5096-5101 6 p.Research output: Contribution to journal › Article › peer-review
74 Scopus citations -
Real-time single-molecule observation of rolling-circle DNA replication
Tanner, N. A., Loparo, J. J., Hamdan, S., Jergic, S., Dixon, N. E. & van Oijen, A. M., Mar 24 2009, In: Nucleic acids research. 37, 4, e27.Research output: Contribution to journal › Article › peer-review
57 Scopus citations
Prizes and Honors
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Several traveling awards to attend conferences, Research School of Chemistry, Australian National University
Hamdan, Samir (Recipient), 1998
Prize: Scientific Recognition › Travel Grant
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Teaching assistant award, Research School of Chemistry, Australian National University
Hamdan, Samir (Recipient), 1998
Prize: Award or Honor › Teaching Award
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Three of his publications received publicity (F1000Prime Article Recommendations )
Hamdan, Samir (Recipient), 2013
Prize: Scientific Recognition › Other Achievement
Research News
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DNA replication under the microscope
Samir Hamdan & Muhammad Tehseen
11/21/21 → 01/2/22
8 items of Media coverage
Press/Media: Press / Media
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News Cryo-EM Enables Team To Study How DNA Replication Machinery Assembles Cryogenic electron microscopy (cryo-EM) has enabled researchers to study how the DNA replication machinery assembles at sites where DNA is damaged.
Samir Hamdan & Muhammad Tehseen
11/23/21
1 item of Media coverage
Press/Media: Press / Media
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DNA Replication under the Microscope
Samir Hamdan & Muhammad Tehseen
11/22/21 → 11/23/21
3 items of Media coverage
Press/Media: Press / Media
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Resuelven la estructura de las polimerasas que aseguran la estabilidad de los genes en la multiplicación celular
Samir Hamdan, Masateru Takahashi, Mohamed Abdelmaboud Sobhy & Muhammad Tehseen
10/28/21
1 item of Media coverage
Press/Media: Press / Media
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KAUST-developed COVID-19 test kit to have big impact for Saudi Arabia
Samir Hamdan, Arnab Pain & Pierre Magistretti
10/5/21 → 10/6/21
2 items of Media coverage
Press/Media: Press / Media
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Who’s Who: Monther Mahmoud Tayeb, PR exec at Saudi Electricity Company
Samir Hamdan, Arnab Pain & Pierre Magistretti
10/6/21
1 item of Media coverage
Press/Media: Press / Media
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Taxpayers must submit May returns by Oct. 10
Samir Hamdan, Arnab Pain & Pierre Magistretti
10/6/21
1 item of Media coverage
Press/Media: Press / Media
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US Patent Issued to KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY on June 8 for "DNA polymerases from the red sea brine pool" (Saudi Arabia Inventors)
Samir Hamdan & Masateru Takahashi
06/9/21
1 item of Media coverage
Press/Media: Press / Media