Photo of Samir Hamdan
  • Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
19992021

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Personal profile

Research Overview

Professor Hamdan's research interest is focused on the reconstitution, imaging and characterization of multi-protein nucleic acid binding machinaries at the single molecule level. Toward achieving this goal his lab uses an approach that combines conventional biochemical and biophysical tools with wide range of force and fluorescence single-molecule imaging techniques. The ability to observe enzymatic activities in real time at the single molecule level has profoundly changed how biochemical reactions are studied. By eliminating ensemble averaging, the distributions and fluctuations of molecular properties can be characterized, transient intermediates can be observed and identified, and catalytic mechanisms can be elucidated. Applying this multidisciplinary approach will provide a true molecular understanding of the mechanisms involved in replication, repair, and recombination. It will also extend the technique of single-molecule analysis from a few proteins to large multi-protein complexes, often containing many enzymatic activities.

Key Research Areas

Chemical Science

Education

Chemistry, Ph.D., Australian National University

2002

Award Date: Jan 1 2002

Chemistry, M.S., Western Michigan University

1998

Award Date: Jan 1 1998

Chemistry, B.S., Yarmouk University

1995

Award Date: Jan 1 1995

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