The course offers a modern fundamental understanding to the main concepts and practical applications of thermodynamics in materials science. The following major topics are discussed within the frame of this course: review of basic laws of classical thermodynamics, an introduction to phase equilibria including the theory of solutions, chemical reaction and surface and interfacial phenomena. Additionally, an introduction to statistical thermodynamics of gases and condensed matter is provided. The course offers a modern fundamental understanding of the main concepts and practical applications of thermodynamics in materials science. The following major topics are discussed: review of the laws of classical thermodynamics, introduction to statistical thermodynamics phase equilibria, including phase diagrams, theory of solutions, chemical reactions involving gases and condensed matter, Ellingham diagrams, surface and interfacial phenomena, and thermodynamics at the nanoscale. MSE 303 was previously entitled "Statistical Thermodyn & Equalib Process" during Falls of 2011, 2012, 2013, 2014, 2015 and 2016 and Springs of 2012, 2014, 2015, 2016 and 2017.